Because of gonadal mosaicism, the risk of recurrence of achondroplasia in the sibs of achondroplastic children with unaffected parents is presumably higher than twice the mutation rate, but it has not been measured. Data from 11 Canadian genetics centers provide an estimate of 1/443, or 0.02%. Am. J. Med. Genet. 90:250–251, 2000.
No takes yet. Share an insight, caveat, or question.
Mettler et al. (2000) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: