What question did this study set out to answer?

To evaluate the safety and clinical and angiographic effectiveness of intra-arterial papaverine infusion as an alternative to balloon angioplasty for treating cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

December 1, 1992Journal of neurosurgery

Treatment of cerebral vasospasm with intra-arterial papaverine

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Authors

NKNeal F. KassellCornell University GHGregory A. HelmUniversity of Virginia Health System NSNathan E. SimmonsDartmouth–Hitchcock Medical Center

Discussion

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Implication

Case series reveals angiographic and neurological improvement with intra-arterial papaverine in subarachnoid hemorrhage vasospasm, indicating a viable alternative to balloon angioplasty.

Key Points

To evaluate the safety and clinical and angiographic effectiveness of intra-arterial papaverine infusion as an alternative to balloon angioplasty for treating cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Administered intra-arterial papaverine infusions to N=12 patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage who were candidates for balloon angioplasty.
Infused a target dose of 300 mg of papaverine over a 1-hour duration into affected cerebral vascular territories.
Marked angiographic reversal of arterial narrowing occurred in 8 of 12 patients, with 4 patients demonstrating dramatic reversal of profound neurological deficits.
Two patients experienced recurrent severe vasospasm 5 days post-infusion that partially responded to retreatment, and 2 patients developed transient focal deficits during infusion that resolved spontaneously within hours.
Vasospasm in the posterior circulation and middle cerebral artery distribution exhibited greater responsiveness to papaverine than spasm in anterior cerebral arteries.

Cite This Study

Kassell et al. (1992) studied this question.

synapsesocial.com/papers/6a6ff3aeac440176ef289b00 https://doi.org/10.3171/jns.1992.77.6.0848

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Implication

Case series reveals angiographic and neurological improvement with intra-arterial papaverine in subarachnoid hemorrhage vasospasm, indicating a viable alternative to balloon angioplasty.

Treatment of cerebral vasospasm with intra-arterial papaverine

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of cerebral vasospasm with intra-arterial papaverine

Discussion

Member takes

Implication

Key Points

Cite This Study

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