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April 1, 1999Journal of Biological ChemistryOpen Access

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

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Authors

SSShannon L. StroscheinUniversity of California, BerkeleyWWWei WangJiangxi University of Traditional Chinese MedicineKLKunxin LuoUniversity of California, Berkeley

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Stroschein et al. (1999) studied this question.

synapsesocial.com/papers/6a6ff3f95671bbf00bc29ff6https://doi.org/10.1074/jbc.274.14.9431
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.1991 · 319 citations
  2. 2CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells1998 · 180 citations
  3. 3Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC41997 · 206 citations
  4. 4Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter1998 · 139 citations
  5. 5Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer1998 · 567 citations