What question did this study set out to answer?

To evaluate the feasibility of noninvasively measuring blood and tissue glucose concentrations in diabetic subjects using transmission near-infrared spectroscopy and chemometric analysis.

September 1, 1992Clinical Chemistry

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation

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Authors

MRMyranda RobinsonUniversity of New Mexico RER. Philip EatonUniversity of New Mexico DHDavid M. HaalandNew Mexico State University

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Implication

Feasibility study demonstrates accurate noninvasive glucose estimation in diabetic subjects using near-infrared spectroscopy, suggesting a viable alternative to needle-based testing.

Key Points

To evaluate the feasibility of noninvasively measuring blood and tissue glucose concentrations in diabetic subjects using transmission near-infrared spectroscopy and chemometric analysis.
Evaluated three spectrometer setups: a Fourier-transform infrared spectrometer with an indium antimonide detector, a grating monochromator with a silicon array detector, and a grating monochromator with fiber-optic sampling.
Acquired near-infrared spectra through the fingers of diabetic subjects during a meal-tolerance test across plasma glucose concentrations ranging from 2.5 to 27 mmol/L.
Analyzed spectral transmission data using partial least squares and principal component regression multivariate calibrations.
The best multivariate calibration achieved a cross-validated average absolute error in glucose concentration of 1.1 mmol/L across a measured range of 2.5 to 27 mmol/L.
Transmission near-infrared spectroscopy coupled with chemometrics successfully tracked physiological glucose changes noninvasively.

Cite This Study

Robinson et al. (1992) studied this question.

synapsesocial.com/papers/6a6ff542439bab0cabc2f719 https://doi.org/10.1093/clinchem/38.9.1618

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Implication

Feasibility study demonstrates accurate noninvasive glucose estimation in diabetic subjects using near-infrared spectroscopy, suggesting a viable alternative to needle-based testing.

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

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