Transgenic Analysis of the Role of FKBP12.6 in Cardiac Function and Intracellular Calcium Release

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Structured PICO

Population

FKBP12.6-deficient mice with cardiac hypertrophy and a transgenic mouse line with cardiac specific overexpression of FKBP12.6 (MHC-FKBP12.6)

Intervention

Cardiac specific overexpression of FKBP12.6 using α-myosin heavy chain (αMHC) promoter

Outcome

Cardiac function, exercise-induced arrhythmia, sudden cardiac death, and cardiomyocyte calcium releasesurrogate

Cardiac-specific overexpression of FKBP12.6 rescues abnormal cardiac hypertrophy and calcium release in FKBP12.6-deficient mice.

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Does not support FKBP12.6-targeted therapies in patients; leaves open translation to human hypertrophy or arrhythmia prevention.

Liu et al. (2011) studied this question.

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