Why the study?
Does spironolactone or hydrochlorothiazide reduce blood pressure more effectively in hypertensive patients based on baseline plasma renin activity?
Population
51 hypertensive patients
Comparison
Spironolactone 200 mg daily for 12 weeks vs Hydrochlorothiazide 100 mg daily for 12 weeks
Design
Cohort
Follow-up
12 weeks
Authors
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May inform renin-guided diuretic selection in hypertension; leaves open need for randomized confirmation.
Does spironolactone or hydrochlorothiazide reduce blood pressure more effectively in hypertensive patients based on baseline plasma renin activity?
Both spironolactone and hydrochlorothiazide are more effective in reducing blood pressure in hypertensive patients with low and low-normal renin activity compared to those with higher renin activity.
E. V. Adlin (1972) studied this question.