Population
Mice with or without reduction of RyR-2 gene (RyR-2+/- and wild-type)
Comparison
Pressure overload induced by constriction of… vs Wild-type mice undergoing the same pressure…
Design
Preclinical
Follow-up
3 weeks
Authors
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RyR2 haploinsufficiency impairs adaptation in pressure-overload models; hypothesis-generating for human therapies, should not yet change practice.
RyR-2 contributes to the development of cardiac hypertrophy and adaptation of cardiac function during pressure overload through regulation of sarcoplasmic reticulum Ca2+ release and survival signaling.
Zou et al. (2011) studied this question.
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