What question did this study set out to answer?

To review the intracellular signaling cascades that regulate transcription factor activity and gene expression in cardiac myocytes during physiological adaptation and stress-induced cardiac disease.

April 20, 2007Journal of Cellular Physiology

Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

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Population

Cardiac myocytes

Design

Review

Authors

ACAngela ClerkHeart Failure / Cardiomyopathy TCTimothy E. CullingfordImperial College London SFStephen J. FullerNepean Hospital

Discussion

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Implication

Consolidates myocyte signaling knowledge; leaves open targeted therapeutic validation in clinical heart failure.

Key Points

To review the intracellular signaling cascades that regulate transcription factor activity and gene expression in cardiac myocytes during physiological adaptation and stress-induced cardiac disease.
Synthesized molecular evidence detailing cytoplasmic and nuclear signaling pathways that respond to cardiac pathophysiological stimuli.
Evaluated regulatory networks involving mitogen-activated protein kinases, Akt, calcineurin/NFAT, and JAK/STAT in terminally differentiated cardiac myocytes.
Pathways such as MAPK and Akt transduce cytoplasmic signals directly to nuclear-localized transcription factors in response to myocardial stress.
Cascades including calcineurin/NFAT and JAK/STAT stimulate the translocation of transcription factors into the nucleus to drive hypertrophic growth or apoptosis.

Structured PICO

Population

Cardiac myocytes

This review provides a comprehensive overview of the intracellular signaling pathways that modulate gene expression and drive hypertrophic or apoptotic responses in cardiac myocytes.

Cite This Study

Clerk et al. (2007) studied this question.

synapsesocial.com/papers/6a6ff6a66ceb2bbd16dfc36c https://doi.org/10.1002/jcp.21094

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Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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