Why the study?
Quantitative MR imaging techniques provide meaningful pathophysiologic information about brain microstructure, serving as a tool to evaluate myelin and iron changes in MS.
How do quantitative MR imaging techniques evaluate brain microstructure and pathophysiology in patients with multiple sclerosis?
How do quantitative MR imaging techniques evaluate brain microstructure and pathophysiology in patients with multiple sclerosis?
Quantitative MR imaging provides valuable insights into the pathophysiology of multiple sclerosis by evaluating changes in myelin and iron content.
Quantitative MR imaging techniques allow evaluating different aspects of brain microstructure, providing meaningful information about the pathophysiology of damage in CNS disorders. In the study of patients with MS, quantitative MR imaging techniques represent an invaluable tool for studying changes in myelin and iron content occurring in the context of inflammatory and neurodegenerative processes. In the first section of this review, we summarize the physics behind quantitative MR imaging, here defined as relaxometry and quantitative susceptibility mapping, and describe the neurobiological correlates of quantitative MR imaging findings. In the second section, we focus on quantitative MR imaging application in MS, reporting the main findings in both the gray and white matter compartments, separately addressing macroscopically damaged and normal-appearing parenchyma.
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Tranfa et al. (2022) studied this question.
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