July 25, 2001European Journal of Neurology
Linking structural, metabolic and functional changes in multiple sclerosis
Why the study?
Do advanced quantitative MR approaches improve the detection of structural, metabolic, and functional changes in patients with multiple sclerosis compared to conventional MRI?
Population
Patients with multiple sclerosis (MS)
Comparison
Advanced quantitative magnetic resonance… vs Conventional magnetic resonance imaging (MRI)
Design
Review
Authors
Discussion
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Member takes
Implication
Does not support routine clinical adoption in MS; leaves open prospective validation of advanced techniques for outcome prediction.
Structured PICO
Do advanced quantitative MR approaches improve the detection of structural, metabolic, and functional changes in patients with multiple sclerosis compared to conventional MRI?
P
Population
Patients with multiple sclerosis (MS)
I
Intervention
Advanced quantitative magnetic resonance approaches (Magnetization transfer imaging [MTI], diffusion-weighted imaging [DWI], magnetic resonance spectroscopy [MRS], functional MRI)
C
Comparator
Conventional magnetic resonance imaging (MRI)
O
Outcome
Detection of structural, metabolic, and functional changes in the brain and spinal cordsurrogate
Advanced quantitative MR techniques provide complementary information to conventional MRI, improving the understanding of structural, metabolic, and functional changes in multiple sclerosis.
Cite This Study
Massimo Filippi (2001) studied this question.