Population
Cells infected with encephalomyocarditis virus (EMCV; a cardiovirus)
Comparison
EMCV infection and expression of viral leader… vs Uninfected cells and poliovirus-infected cells
Design
Preclinical
Authors
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Distinguishes cardiovirus nuclear pore mechanisms from enteroviruses; leaves open whether leader protein targeting informs antiviral or cardiac infection strategies.
Cardioviruses and enteroviruses both alter nucleocytoplasmic traffic but achieve this through strikingly different mechanisms, with cardioviruses relying on the viral leader protein.
Lidsky et al. (2006) studied this question.
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