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Vicodin, a fixed-dose combination analgesic containing acetaminophen, or N-acetyl-p-aminophenol, (APAP) and hydrocodone, is the most frequently recommended opioid pain reliever prescribed by US oral surgeons after the extraction of third molars.1 It was first introduced to the US market in 1978, and today, APAP-hydrocodone combinations (for example, Vicodin, Norco, Lortab, and Zydone) have the dubious reputation of being our nation’s most frequently prescribed analgesics, as well as our nation’s most frequently abused prescription drugs.
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Moore et al. (2016) studied this question.
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