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September 6, 2002Proceedings of the National Academy of SciencesOpen Access

A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

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YTYasuhito TanakaKumamoto University HospitalPTPhuong Oanh T. TranPacific Northwest Diabetes Research InstituteJHJamie S. HarmonBarrow Neurological Institute

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Tanaka et al. (2002) studied this question.

synapsesocial.com/papers/6a6ff9f078a11c550e09c37ahttps://doi.org/10.1073/pnas.192445199
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Also Consider

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  1. 1Role of Oxidative Stress in Development of Complications in Diabetes1991 · 3,717 citations
  2. 2Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells1996 · 133 citations
  3. 3High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress1996 · 315 citations
  4. 4GPx-1 Gene Delivery Modulates NF κ B Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex2001 · 92 citations
  5. 5Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.1996 · 159 citations