What question did this study set out to answer?

To evaluate the impact of two extension spacer devices on regional pulmonary and upper airway aerosol deposition from pressurized inhalers.

September 1, 1981

Deposition of pressurized suspension aerosols inhaled through extension devices.

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Authors

SNStanton NewmanSt George's, University of London FMFolke MorénIntegrative Research Laboratories DPD PaviaFHNW University of Applied Sciences and Arts

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Implication

Clinical study demonstrates that spacer devices enhance conducting airway deposition and decrease throat impaction in obstructive airway disease, indicating improved aerosol drug delivery.

Key Points

To evaluate the impact of two extension spacer devices on regional pulmonary and upper airway aerosol deposition from pressurized inhalers.
Ten subjects with obstructive airway disease inhaled 99mTc-labeled teflon particles (mass median aerodynamic diameter, 3.2 µm) under controlled breathing conditions (N=10).
Aerosol was administered using a conventional actuator alone or attached to either a 10-cm tube or a 22-cm cone extension device.
Whole-body radioaerosol distribution across conducting airways, alveoli, and the oropharynx was measured using a shadowshield whole-body counter.
Deposition of aerosol on the conducting airways was significantly improved by both the 10-cm tube and 22-cm cone spacers compared to the actuator alone.
Initial oropharyngeal deposition was reduced by both spacer configurations across all 10 subjects.
Alveolar deposition of the aerosol remained unchanged between the spacer devices and the actuator alone.

Cite This Study

Newman et al. (1981) studied this question.

synapsesocial.com/papers/6a6ffa8fa528af2d65c3426f https://doi.org/10.1164/arrd.1981.124.3.317

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Implication

Clinical study demonstrates that spacer devices enhance conducting airway deposition and decrease throat impaction in obstructive airway disease, indicating improved aerosol drug delivery.

Deposition of pressurized suspension aerosols inhaled through extension devices.

Discussion

Member takes

Implication

Key Points

Cite This Study

Deposition of pressurized suspension aerosols inhaled through extension devices.

Discussion

Member takes

Implication

Key Points

Cite This Study

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