October 17, 2008Stem CellsOpen Access

Lack of Laminin γ1 in Embryonic Stem Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation and Function

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Population

Cardiomyocytes derived from embryonic stem cells deficient in the LAMC1 gene (laminin gamma1 -/-)

Comparison

LAMC1 gene deficiency (laminin gamma1 knockout) vs Normal/wild-type embryonic stem cell-derived…

Design

Preclinical

Authors

DMDaniela MalanUniversity of Bonn MRMichael ReppelTH Köln - University of Applied Sciences RDRadek DobrowolskiRutgers, The State University of New Jersey

Discussion

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Implication

Preclinical laminin gamma1 data suggest ECM integrity influences conduction; leaves open any role in human arrhythmia substrates or therapies.

Structured PICO

Population

Cardiomyocytes derived from embryonic stem cells deficient in the LAMC1 gene (laminin gamma1 -/-)

Intervention

LAMC1 gene deficiency (laminin gamma1 knockout)

Comparator

Normal/wild-type embryonic stem cell-derived cardiomyocytes (implied)

Outcome

Cardiac muscle differentiation, function, basement membrane formation, and electrical signal propagationsurrogate

Laminin and intact basement membranes are critical for normal extracellular matrix deposition and intact electrical signal propagation in cardiomyocytes, though not essential for differentiation.

Cite This Study

Malan et al. (2008) studied this question.

synapsesocial.com/papers/6a6ffa9078a11c550e09c427 https://doi.org/10.1634/stemcells.2008-0335

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Implication

Preclinical laminin gamma1 data suggest ECM integrity influences conduction; leaves open any role in human arrhythmia substrates or therapies.

Lack of Laminin γ1 in Embryonic Stem Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of Laminin γ1 in Embryonic Stem Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider