What question did this study set out to answer?

Determine whether long-lived CD4 memory T cells arise directly from cytokine-secreting Th1 and Th2 effector intermediates via a linear differentiation model.

January 14, 2008The Journal of Experimental MedicineOpen Access

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

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Authors

MLMax LöhningLeibniz Association AHAhmed N. HegazyHumboldt-Universität zu Berlin DPDaniel D. PinschewerUniversity of Basel

Discussion

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Implication

Murine adoptive transfer study demonstrates functional memory T-cell generation from Th1 and Th2 effector cells in mice, supporting linear CD4 T-cell differentiation for immunotherapy.

Key Points

Determine whether long-lived CD4 memory T cells arise directly from cytokine-secreting Th1 and Th2 effector intermediates via a linear differentiation model.
Purified interferon-gamma-secreting Th1 effectors and IL-4- or IL-10-secreting Th2 effectors primed either in vitro or in vivo.
Adoptively transferred cytokine-secreting effector T cells into normal, nonlymphopenic mice.
Evaluated memory cell persistence, interleukin-7 receptor modulation, cytokine flexibility, and secondary proliferative recall following viral challenge infections.
Purified Th1 and Th2 effector cells avoided activation-induced cell death and successfully generated long-lived virus-reactive memory T cells in vivo.
Effector-derived memory T cells mounted robust proliferative recall, dynamically regulated interleukin-7 receptor levels, and displayed differential immunopathology upon viral challenge.

Cite This Study

Löhning et al. (2008) studied this question.

synapsesocial.com/papers/6a6ffa9831a3df824328457e https://doi.org/10.1084/jem.20071855

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Implication

Murine adoptive transfer study demonstrates functional memory T-cell generation from Th1 and Th2 effector cells in mice, supporting linear CD4 T-cell differentiation for immunotherapy.

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

Discussion

Member takes

Implication

Key Points

Cite This Study

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

Discussion

Member takes

Implication

Key Points

Cite This Study

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