HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism2009 · 347 citations
2. 2Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking2009 · 330 citations
3. 3A novel membrane antigen selectively expressed on terminally differentiated human B cells1994 · 183 citations
4. 4Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 Isolate1994 · 244 citations
5. 5Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion2009 · 223 citations