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April 1, 1997Proceedings of the National Academy of SciencesOpen Access

In differentiated CD4 + T Cells, interleukin 4 production is cytokine-autonomous, whereas interferon γ production is cytokine-dependent

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Authors

JHJane Hu‐LiNational Institutes of HealthHHHua HuangDonghua UniversityJRJohn RyanGeneral Cardiology

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Hu‐Li et al. (1997) studied this question.

synapsesocial.com/papers/6a6ffb181556b380a226dec4https://doi.org/10.1073/pnas.94.7.3189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.1993 · 983 citations
  2. 2The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.1992 · 1,007 citations
  3. 3Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.1995 · 452 citations
  4. 4IL-4 directs the development of Th2-like helper effectors.1990 · 1,264 citations
  5. 5Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.1993 · 186 citations