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April 8, 2010PLoS PathogensOpen Access

Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment

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Authors

MDMathieu DubéInstitut National de Santé Publique du QuébecBRBibhuti Bhusan RoyQueen's UniversityPGPierre Guiot-GuillainMontreal Clinical Research Institute

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Dubé et al. (2010) studied this question.

synapsesocial.com/papers/6a6ffb5bfebe604dd708cb5fhttps://doi.org/10.1371/journal.ppat.1000856
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu2009 · 160 citations
  2. 2HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes2009 · 242 citations
  3. 3Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration2009 · 159 citations
  4. 4Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism2009 · 346 citations
  5. 5Functional role of human immunodeficiency virus type 1 vpu.1989 · 279 citations