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April 4, 2012Clinical EndocrinologyOpen Access

Genetic aspects of adrenocortical tumours and hyperplasias

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Population

Patients with adrenocortical tumours, including adenomas, carcinomas, and adrenal hyperplasia, associated…

Design

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Authors

TMTânia Longo MazzucoUniversidade Estadual de LondrinaJDJulien DurandSanté Publique FranceACAudrey ChapmanRoyal Victoria Hospital

Discussion

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Implication

Supports genetic counselling in hereditary syndromes; leaves open therapeutic targeting of defects in sporadic adrenocortical tumours.

Structured PICO

P
Population
Patients with adrenocortical tumours (ACT), including adenomas, carcinomas, and adrenal hyperplasia, associated with genetic syndromes (e.g., Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, multiple endocrine neoplasia type 1, familial adenomatous polyposis, Carney complex) or sporadic development.

Understanding the genetic alterations in hereditary and sporadic adrenocortical tumours is crucial for genetic counselling and disease management.

Cite This Study

Mazzuco et al. (2012) studied this question.

synapsesocial.com/papers/6a6ffcce78a11c550e09c6e2https://doi.org/10.1111/j.1365-2265.2012.04403.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Molecular Features of the Carney Complex: Diagnostic Criteria and Recommendations for Patient Evaluation2001 · 805 citations
  2. 2Detection of somatic β‐catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)2008 · 106 citations
  3. 3Steroidogenic Factor 1 Overexpression and Gene Amplification Are More Frequent in Adrenocortical Tumors from Children than from Adults2010 · 82 citations
  4. 4Primary Pigmented Nodular Adrenocortical Disease: Paradoxical Responses of Cortisol Secretion to Dexamethasone Occur in Vitro and Are Associated with Increased Expression of the Glucocorticoid Receptor2003 · 107 citations
  5. 5Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome2009 · 104 citations