What question did this study set out to answer?

To determine the incidence, transmission dynamics, and independent risk factors for tuberculosis in an urban homeless cohort using molecular strain typing.

August 1, 2000American Journal of Respiratory and Critical Care Medicine

Tuberculosis in the Homeless

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Authors

AMAndrew R. MossNorfolk and Norwich University Hospital JHJudith A. HahnUniversity of California, San Francisco JTJacqueline P. TulskyUnited Nations Development Programme

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Implication

Cohort study reveals high tuberculosis incidence driven by recent transmission among homeless individuals with HIV, highlighting the need for targeted shelter screening and preventive treatment.

Key Points

To determine the incidence, transmission dynamics, and independent risk factors for tuberculosis in an urban homeless cohort using molecular strain typing.
Followed a longitudinal cohort of 2,774 homeless individuals first evaluated between 1990 and 1994, monitoring incident tuberculosis cases from 1992 through 1996.
Identified risk factors using tuberculin skin testing (TST) and HIV serological screening.
Evaluated recent transmission versus reactivation using restriction fragment length polymorphism (RFLP) molecular fingerprinting.
Observed 25 incident cases yielding an annual rate of 270 per 100,000 (350/100,000 in African Americans, 450/100,000 in other nonwhites, and 60/100,000 in whites), with 10 cases occurring in HIV-seropositive individuals.
Identified HIV infection, African American or other nonwhite ethnicity, positive TST results, age, and education level as independent risk factors for active disease.
Found clustered RFLP patterns in 60% of all cases, including 77% of African American cases and 88% of HIV-seropositive cases, indicating recent transmission and rapid progression.

Cite This Study

Moss et al. (2000) studied this question.

synapsesocial.com/papers/6a6fffabf44fa9f079dd8428 https://doi.org/10.1164/ajrccm.162.2.9910055

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Implication

Cohort study reveals high tuberculosis incidence driven by recent transmission among homeless individuals with HIV, highlighting the need for targeted shelter screening and preventive treatment.

Tuberculosis in the Homeless

Discussion

Member takes

Implication

Key Points

Cite This Study

Tuberculosis in the Homeless

Discussion

Member takes

Implication

Key Points

Cite This Study

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