What question did this study set out to answer?

To investigate how transforming growth factor beta1 regulates triggering receptor expression on natural killer cells and alters their cytotoxic killing of dendritic and tumor cells.

March 19, 2003Proceedings of the National Academy of SciencesOpen Access

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

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Authors

RCRoberta CastriconiIstituto Giannina Gaslini CCClaudia CantoniBarrow Neurological Institute MCMariella Della ChiesaOspedale Policlinico San Martino

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Implication

In vitro experimental study demonstrates that TGF-beta1 downregulates NK cell activating receptors NKp30 and NKG2D, highlighting how dendritic cells may resist natural killer cell cytotoxicity.

Key Points

To investigate how transforming growth factor beta1 regulates triggering receptor expression on natural killer cells and alters their cytotoxic killing of dendritic and tumor cells.
Assessed surface expression and transcriptional regulation of triggering receptors (NKp30, NKG2D, NKp46) on natural killer cells after treatment with transforming growth factor beta1.
Measured natural killer cell-mediated cytotoxic lysis against dendritic cells and different susceptible tumor cell lines.
Transforming growth factor beta1 selectively downregulated surface expression of NKp30 through transcriptional gene repression and partially reduced NKG2D without altering NKp46.
Downregulation of NKp30 significantly inhibited natural killer cell killing of dendritic cells, whereas tumor cell lysis varied according to NKp30 and NKG2D receptor dependence.

Cite This Study

Castriconi et al. (2003) studied this question.

synapsesocial.com/papers/6a7000b535aa2c282ce14f0e https://doi.org/10.1073/pnas.0730640100

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Implication

In vitro experimental study demonstrates that TGF-beta1 downregulates NK cell activating receptors NKp30 and NKG2D, highlighting how dendritic cells may resist natural killer cell cytotoxicity.

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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