An Effective Treatment of Severe Intractable Bleeding After Valve Repair by One Single Dose of Activated Recombinant Factor VII

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Why the study?

Does a single dose of recombinant factor VIIa stop intractable bleeding in a patient after heart valve repair?

Population

1 65-year-old man with severe mitral and tricuspid regurgitation who experienced intractable bleeding after…

Design

Case_report

Follow-up

12 hours post-administration

Authors

Discussion

May support rFVIIa rescue in refractory post-cardiac surgery bleeding; hypothesis-generating and requires randomized confirmation.

Does a single dose of recombinant factor VIIa stop intractable bleeding in a patient after heart valve repair?

Population

1 65-year-old man with severe mitral and tricuspid regurgitation who experienced intractable bleeding after heart valve repair.

Intervention

Recombinant factor VIIa (rFVIIa) 90 μg/kg as a single IV dose.

Outcome

Cessation of bleeding (blood loss via chest drains)

A single bolus injection of 90 μg/kg recombinant FVIIa may be an effective rescue treatment for massive intractable bleeding after cardiac surgery.

Hendriks et al. (2001) studied this question.

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