Why the study?
Do genetic mutations in ColVa1 and ColXIa1 affect ventricular myocardial morphogenesis and heart valve development in mice?
Do genetic mutations in ColVa1 and ColXIa1 affect ventricular myocardial morphogenesis and heart valve development in mice?
ColVa1 and ColXIa1 are required for normal myocardial morphogenesis and heart valve development, with their deficiency leading to morphological defects and compensatory type I collagen deposition.
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Mouse ColVa1/ColXIa1 defects should not guide human care; leaves open their role in congenital cardiac morphogenesis.
Lincoln et al. (2006) studied this question.
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