Prognostic comparison between implantable cardioverter‐defibrillator and amiodarone in cancer patients

Figures

• 

  FIGURE 1. Study population. ICD, Implantable cardioverter‐defibrillator.

• 

  FIGURE 2. Kaplan–Meier curves stratified for 5‐year all‐cause death. We used a multivariable Cox proportional hazard model to compare the impact of ICD with Amiodarone on long‐term all‐cause mortality (5 years). Multivariable model: Adjusted for age, gender, diabetes, chronic kidney disease, prior myocardial infarction, cardiomyopathy, NYHA class II or more, VT/VF, cancer stage: In situ or localized, interval from diagnosis of cancer to treatment, and medications such as β‐blockers, ACEs, ARBs, and MRAs. ACEs, angiotensin‐converting enzyme inhibitors; ARBs, angiotensin II receptor blockers; CI, confidence interval; HR, hazard ratio; ICD, Implantable cardioverter‐defibrillator; MRAs, mineralocorticoid receptor antagonists; NYHA, New York Heart Association; VF, ventricular fibrillation; VT, ventricular tachycardia.

• 

  FIGURE 3. Kaplan–Meier curves stratified by cancer stages (stage: In situ or localized and stage: Regional or distant). Panel (A) indicates Kaplan–Meier curves for cancer stage: In situ or localized. Panel (B) indicates Kaplan–Meier curves for cancer stage: Regional or distant. We used a multivariable Cox proportional hazard model to compare the impact of ICD with Amiodarone on long‐term all‐cause mortality (5 years). Multivariable model: Adjusted for age, gender, diabetes, chronic kidney disease, prior myocardial infarction, chronic heart failure, VT/VF, interval from diagnosis of cancer to treatment. CI, confidence interval; HR, hazard ratio; ICD, Implantable cardioverter‐defibrillator; VF, ventricular fibrillation; VT, ventricular tachycardia.

• 

  FIGURE 4. Kaplan–Meier curves after propensity score matching. Propensity score was estimated for each patient by logistic regression using the following parameters: age, gender, cancer stage: In situ or localized, cancer stage: Regional, cancer stage: Distant, interval from diagnosis of cancer to treatment, cardiomyopathy, VT/VF. Based on the propensity score, 1:1 matching was performed between patients with Amiodarone and ICD. We used a univariable Cox proportional hazard model to compare the impact of ICD with Amiodarone on long‐term all‐cause mortality (5 years). CI, confidence interval; HR, hazard ratio; ICD, Implantable cardioverter‐defibrillator; VF, ventricular fibrillation; VT, ventricular tachycardia.