Key result
Prolonged hypoglossal nerve conduction latency is linked to greater sleep-disordered breathing severity after acute ischemic stroke.
Cross-Sectional (n=52)
OBJECTIVE: This cross-sectional study of acute ischemic stroke patients examined relationships between hypoglossal nerve conduction, sleep-disordered breathing (SDB), and its severity. METHODS: Patients within 7 days of stroke underwent nocturnal respiratory monitoring with the ApneaLink device and hypoglossal nerve conduction studies. RESULTS: Eighteen of 52 subjects (35% [95% confidence interval: 22%, 49%]) had an abnormal hypoglossal amplitude and 23 (44% [95% confidence interval: 30%, 59%]) had an abnormal hypoglossal latency. No differences were identified in hypoglossal nerve latency or amplitude between those with (n = 26) and without (n = 26) significant SDB, defined by an apnea-hypopnea index ≥ 15. However, hypoglossal nerve conduction latency was associated (linear regression p < 0.05) with SDB severity as reflected by the apnea-hypopnea index. CONCLUSIONS: Acute ischemic stroke patients have a high prevalence of hypoglossal nerve dysfunction. Further studies are needed to explore whether hypoglossal nerve dysfunction may be a cause or consequence of SDB in stroke patients and whether this association can provide further insight into the pathophysiology of SDB in this population.
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Brown et al. (2014) conducted a cross-sectional in acute ischemic stroke (n=52). Significant sleep-disordered breathing (apnea-hypopnea index ≥ 15) vs. No significant sleep-disordered breathing was evaluated on Differences in hypoglossal nerve latency or amplitude and association with sleep-disordered breathing severity (p=<0.05). Hypoglossal nerve conduction latency was significantly associated with sleep-disordered breathing severity in acute ischemic stroke patients (P<0.05).
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