September 1, 1998Journal of Biological ChemistryOpen Access

Localization in the II-III Loop of the Dihydropyridine Receptor of a Sequence Critical for Excitation-Contraction Coupling

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Structured PICO

Population

Dysgenic myotubes

Intervention

Expression of chimeric and mutant dihydropyridine receptor (DHPR) cDNA constructs (e.g., alanine-substituted skeletal DHPR, chimeric DHPR with skeletal residues 725-742)

Comparator

Expression of other chimeric DHPR constructs (e.g., chimera with skeletal residues 711-732 or 734-765)

Outcome

Ability to mediate skeletal-type excitation-contraction (EC) couplingsurrogate

Residues 725-742 in the II-III loop of the skeletal dihydropyridine receptor are critical for skeletal-type excitation-contraction coupling.

Discussion

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Implication

Pinpoints a domain for skeletal EC coupling models; leaves open relevance to cardiac muscle or clinical translation.

Cite This Study

Nakai et al. (1998) studied this question.

synapsesocial.com/papers/6a7005db2163a0a01bc43e9a https://doi.org/10.1074/jbc.273.39.24983

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Localization in the II-III Loop of the Dihydropyridine Receptor of a Sequence Critical for Excitation-Contraction Coupling

Structured PICO

Discussion

Implication

Cite This Study

Localization in the II-III Loop of the Dihydropyridine Receptor of a Sequence Critical for Excitation-Contraction Coupling

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider