What question did this study set out to answer?

To review the molecular mechanisms through which tomato lycopene modulates inflammatory signaling cascades across cellular, animal, and clinical settings.

June 16, 2010Current Medicinal Chemistry

Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

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Authors

PPPaola PalozzaUniversità Cattolica del Sacro Cuore NPNadia ParroneUniversità Cattolica del Sacro Cuore ACAssunta CatalanoUniversità Cattolica del Sacro Cuore

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Implication

Literature review demonstrates inflammatory signaling modulation by tomato lycopene across cellular and clinical models, highlighting its potential in chronic disease prevention.

Key Points

To review the molecular mechanisms through which tomato lycopene modulates inflammatory signaling cascades across cellular, animal, and clinical settings.
Synthesized findings from in vitro cell models, in vivo animal models, and clinical trials examining tomato lycopene administration.
Evaluated carotenoid dose dependencies, cellular microenvironments, and impacts on key inflammatory mediators and transcription factors.
Lycopene suppresses inflammatory cascades by lowering reactive oxygen species, down-regulating cyclooxygenase and lipoxygenase expression, and reducing pro-inflammatory cytokine production.
Carotenoid action inhibits NF-kB, AP-1, and MAPK pathways, which blunts inducible nitric oxide synthase activity and promotes apoptosis in activated immune cells.

Cite This Study

Palozza et al. (2010) studied this question.

synapsesocial.com/papers/6a7006368031ec7bb1dc12a5 https://doi.org/10.2174/092986710791556041

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Implication

Literature review demonstrates inflammatory signaling modulation by tomato lycopene across cellular and clinical models, highlighting its potential in chronic disease prevention.

Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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