What question did this study set out to answer?

To identify cellular mechanisms within the bone marrow that drive early endotoxin tolerance following sublethal lipopolysaccharide exposure.

December 1, 1985The Journal of Immunology

Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools.

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Authors

GMG S MadonnaUniversity of Naples Federico II SVS N VogelNational Institutes of Health Clinical Center

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Implication

Experimental study reveals expansion of bone marrow macrophage precursors during endotoxin tolerance in mice, suggesting immature monocytic cells drive hyporesponsiveness.

Key Points

To identify cellular mechanisms within the bone marrow that drive early endotoxin tolerance following sublethal lipopolysaccharide exposure.
Mice were injected with a priming dose of 25 µg Escherichia coli K235 lipopolysaccharide (LPS) followed by a secondary challenge dose at various time intervals up to 8 days.
Bone marrow cell size profiles, density gradient sedimentation, and cytological evaluations were conducted to characterize changes in macrophage progenitor populations.
Hyporesponsiveness to LPS challenge peaked at 3 to 4 days post-initial exposure and resolved fully by day 8.
Tolerance coincided with an accumulation of significantly larger, denser bone marrow cells identified as immature monocytic macrophage progenitors, an increase that persisted through a secondary LPS challenge.

Cite This Study

Madonna et al. (1985) studied this question.

synapsesocial.com/papers/6a70088878a11c550e09d2e7 https://doi.org/10.4049/jimmunol.135.6.3763

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Implication

Experimental study reveals expansion of bone marrow macrophage precursors during endotoxin tolerance in mice, suggesting immature monocytic cells drive hyporesponsiveness.

Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools.

Discussion

Member takes

Implication

Key Points

Cite This Study

Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools.

Discussion

Member takes

Implication

Key Points

Cite This Study

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