Is platelet activity on admission associated with intraventricular hemorrhage and death in patients with intracerebral hemorrhage?
Reduced platelet activity on admission in patients with intracerebral hemorrhage is associated with an increased risk of intraventricular hemorrhage and death at 14 days.
There are few data on platelet function in intracerebral hemorrhage (ICH). We prospectively enrolled 69 patients with ICH and measured platelet function on admission. Aspirin use before ICH was associated with reduced platelet activity. Less platelet activity was associated with intraventricular hemorrhage (516.5 interquartile range (IQR), 454-629.25 vs 637 IQR, 493-654 aspirin reaction units; p = 0.04) and death at 14 days (480.5 IQR, 444.5-632.5 vs 626 IQR, 494-652 aspirin reaction units; p = 0.04). Objective measures of platelet function on admission are associated with intraventricular hemorrhage and death after ICH.
Naidech et al. (2009) studied this question.