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Embryonic stem cells (ESCs) are derived from the inner-cell-mass (ICM) of blastocysts. ESC and induced pluripotent stem cell (iPSC) lines are immortal, meaning that they have unlimited proliferation potential. They are also pluripotent; that is, they can differentiate into lineages derived from all 3 major germ layers of the embryo. Consequently, these cells have been widely investigated in the development of regenerative medicine therapies. Human ESCs have been regarded as important research tools for the investigation into early development of the human embryo.
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Kao et al. (2017) studied this question.
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