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Summary1) Mitotic activity occurs in adult mast cells of the mesentery of rats after moderate intraperitoneal doses of the histamine liberator, compound 48/80. After larger doses, which cause disintegration of mesenteric mast cells, mitoses are found in mast cells of the subcutaneous tissue. 2) Replacement of cells after disintegration appears to be by heteroplastic differentiation of lymphocytes or undifferentiated mesenchymal cells or both.
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Hunt et al. (1957) studied this question.
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