What question did this study set out to answer?

To examine the association between serum 25-hydroxyvitamin D concentrations and both the risk of developing chronic obstructive pulmonary disease and subsequent mortality.

June 1, 2023BMJ Open Respiratory ResearchOpen Access

Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study

View Full Paper

Ask AI

Bookmark

To examine the association between serum 25-hydroxyvitamin D concentrations and both the risk of developing chronic obstructive pulmonary disease and subsequent mortality.
Prospective cohort analysis of N=403,648 UK Biobank participants free of COPD at baseline with follow-up through September 30, 2021 (median 12.3 years).
Multivariable-adjusted Cox proportional hazards models and restricted cubic splines evaluated season-standardised serum 25(OH)D concentrations in relation to incident COPD and survival.
Across 11,008 recorded incident COPD cases, participants in the lowest 25(OH)D quintile had a higher COPD risk than those in the fourth quintile (HR 1.23, 95% CI 1.16 to 1.31), with stronger associations observed in men and current smokers (both p for interaction < 0.05).
Among individuals with COPD, the lowest 25(OH)D quintile was associated with a 38% elevated risk of all-cause mortality compared to the fourth quintile (HR 1.38, 95% CI 1.22 to 1.56).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Prospective cohort study reveals low vitamin D levels increase chronic obstructive pulmonary disease risk and mortality, suggesting a potential protective role.

Cite This Study

Zhu et al. (2023) studied this question.

synapsesocial.com/papers/6a7009d6660549caf2c495aa https://doi.org/10.1136/bmjresp-2023-001684

View Full Paper

Ask AI

Bookmark

Implication

Prospective cohort study reveals low vitamin D levels increase chronic obstructive pulmonary disease risk and mortality, suggesting a potential protective role.

Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study

Key Points

Discussion

Implication

Cite This Study

Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider