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November 1, 1995Journal of General Virology

Development of an ELISA to detect MX virus, a human calicivirus in the Snow Mountain agent genogroup

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Why the study?

Can an ELISA using hyperimmune antisera to the recombinant MX virus capsid accurately detect SMA genogroup human caliciviruses in stool specimens?

Population

Stool specimens from children with diarrhoea (23 from Norfolk, Virginia, and 20 from the United Kingdom)

Comparison

rMX ELISA using hyperimmune antisera to the… vs Reverse transcription-polymerase chain reaction…

Design

Other

Authors

XJXi JiangTongji UniversityDCDavid CubittGreat Ormond Street Hospital for Children NHS Foundation TrustJHJian HuJiangsu University

Discussion

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Implication

rMX ELISA supports SMA genogroup detection in stool; leaves open broader validation before routine use.

Structured PICO

Can an ELISA using hyperimmune antisera to the recombinant MX virus capsid accurately detect SMA genogroup human caliciviruses in stool specimens?

P
Population
Stool specimens from children with diarrhoea (23 from Norfolk, Virginia, and 20 from the United Kingdom)
I
Intervention
rMX ELISA using hyperimmune antisera to the recombinant MX virus (rMX) capsid
C
Comparator
Reverse transcription-polymerase chain reaction (RT-PCR) and electron microscopy
O
Outcome
Detection of Snow Mountain agent (SMA) genogroup human caliciviruses (HuCVs)surrogate

The newly developed rMX ELISA is an effective tool for detecting Snow Mountain agent genogroup human caliciviruses in clinical stool specimens.

Cite This Study

Jiang et al. (1995) studied this question.

synapsesocial.com/papers/6a700a1de5469ee92be0d03ehttps://doi.org/10.1099/0022-1317-76-11-2739
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression, self-assembly, and antigenicity of a snow mountain agent-like calicivirus capsid protein1995 · 160 citations
  2. 2Enzyme immunoassay using baculovirus‐expressed human calicivirus (Mexico) for the measurement of IgG responses and determining its seroprevalence in London, UK1995 · 70 citations
  3. 3Sequence similarity of human caliciviruses and small round structured viruses1994 · 56 citations
  4. 4Sequence diversity of small, round-structured viruses in the Norwalk virus group1994 · 244 citations
  5. 5Detection and differentiation of antigenically distinct small round-structured viruses (Norwalk-like viruses) by reverse transcription-PCR and southern hybridization1995 · 384 citations