What question did this study set out to answer?

To review the biological mechanisms by which acid sphingomyelinase drives ceramide signaling and examine its contribution to common human diseases and therapeutic development.

June 20, 2008The FASEB JournalOpen Access

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

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To review the biological mechanisms by which acid sphingomyelinase drives ceramide signaling and examine its contribution to common human diseases and therapeutic development.
Review of mechanistic evidence from acid sphingomyelinase knockout (ASMKO) mouse models and cell lines derived from patients with Niemann-Pick disease.
Evaluation of molecular pathways involving enzyme translocation, sphingomyelin hydrolysis, and lipid microdomain organization across clinical and preclinical disease settings.
Acid sphingomyelinase translocates to the outer membrane leaflet to hydrolyze sphingomyelin into ceramide, driving lipid microdomain coalescence and initiating apoptotic signal transduction.
Genetic loss of acid sphingomyelinase activity protects cells and knockout animals from stress-induced and developmental apoptosis.
Dysregulated acid sphingomyelinase activity promotes pathophysiology in sepsis, cancer, cardiovascular, pulmonary, liver, and neurological disorders, supporting the development of targeted inhibitors.

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Implication

Review demonstrates the central role of acid sphingomyelinase in ceramide-mediated apoptosis across multiple diseases, highlighting its therapeutic potential as a drug target.

Cite This Study

Smith et al. (2008) studied this question.

synapsesocial.com/papers/6a700a66439bab0cabc2fe5b https://doi.org/10.1096/fj.08-108043

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Implication

Review demonstrates the central role of acid sphingomyelinase in ceramide-mediated apoptosis across multiple diseases, highlighting its therapeutic potential as a drug target.

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

Key Points

Discussion

Implication

Cite This Study

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

Key Points

Discussion

Implication

Cite This Study

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