Population
KCa3.1 channel (preclinical model)
Comparison
Substituted cysteine accessibility method using… vs Open versus closed channel configurations
Design
Preclinical
Authors
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No immediate clinical implications from animal data; leaves open the precise role of V282 in mammalian KCa3.1 gating.
The closed KCa3.1 channel pore structure features a narrow passage centered at V282 that allows diffusion of small reagents, arguing against the C-terminal end of S6 forming an obstructive barrier to K+ ions.
Klein et al. (2007) studied this question.
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