Why the study?
The study was designed to explore the association of Life's Essential 8 (LE8) with stroke and all-cause mortality, and to assess whether it has an advantage over Life's Simple 7 (LS7).
Does Life's Essential 8 better predict stroke and all-cause mortality compared to Life's Simple 7 in the general population?
Does Life's Essential 8 better predict stroke and all-cause mortality compared to Life's Simple 7 in the general population?
Life's Essential 8 outperforms the older Life's Simple 7 metric in discriminating stroke risk, with oxidative stress and inflammation partially mediating this association.
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LE8 may refine stroke risk stratification in practice; leaves open prospective validation before guideline adoption.
Yuan et al. (2025) studied this question.
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