Why the study?
Do the SRSV(II)-AD and IDEIA NLV ELISA kits have sufficient sensitivity and specificity to replace RT-PCR for routine diagnosis of human norovirus in stool samples?
Population
142 stool samples
Comparison
SRSV-AD and IDEIA NLV enzyme-linked… vs Reverse transcription-PCR (RT-PCR)
Design
Cross-sectional
Authors
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Neither ELISA kit meets criteria to replace RT-PCR for norovirus; leaves open need for improved rapid diagnostics.
Do the SRSV(II)-AD and IDEIA NLV ELISA kits have sufficient sensitivity and specificity to replace RT-PCR for routine diagnosis of human norovirus in stool samples?
Neither the Denka nor the Dako ELISA kits possess the necessary performance characteristics to replace RT-PCR for the routine diagnosis of human noroviruses.
Burton-MacLeod et al. (2004) studied this question.
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