Why the study?
Does venlafaxine XR compared to paroxetine reduce heart rate variability in depressed outpatients?
Population
49 depressed outpatients (44 evaluable)
Comparison
Venlafaxine XR up to 225 mg daily vs Paroxetine up to 40 mg daily
Design
RCT, Randomly assigned, Double-blind
Authors
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Venlafaxine XR warrants greater caution than paroxetine for autonomic effects; confirms differential HRV impact in depressed outpatients.
Does venlafaxine XR compared to paroxetine reduce heart rate variability in depressed outpatients?
Venlafaxine XR significantly reduces parasympathetic heart rate variability compared to paroxetine in depressed outpatients, likely related to norepinephrine transporter occupancy.
Davidson et al. (2005) studied this question.
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