What question did this study set out to answer?

To determine whether common genetic variants in the COQ2 gene are associated with individual susceptibility to statin-related muscle intolerance and myopathy.

March 21, 2007Lipids in Health and DiseaseOpen Access

Genetic determinants of statin intolerance

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Why the study?

Is genetic variation in the COQ2 gene associated with statin intolerance?

Population

291 subjects, comprising 133 who developed myopathy on statin monotherapy and 158 matched controls who…

Comparison

Genetic variation in the COQ2 gene vs Matched controls who tolerated statins without…

Design

Case-control

Authors

JOJisun OhDaegu-Gyeongbuk Medical Innovation Foundation MBMatthew R. BanBroad Institute BMBrooke A. MiskieWestern University

Discussion

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Implication

COQ2 homozygosity was associated with statin intolerance; leaves open pharmacogenetic testing utility pending prospective validation.

Key Points

To determine whether common genetic variants in the COQ2 gene are associated with individual susceptibility to statin-related muscle intolerance and myopathy.
Conducted a case-control pharmacogenetic study comparing 133 subjects with myopathy on statin monotherapy against 158 matched statin-tolerant controls.
Genotyped two single nucleotide polymorphisms (SNP1 and SNP2) and evaluated a 2-SNP haplotype within the COQ2 gene.
Homozygotes for the rare allele of SNP1 had an elevated risk of statin intolerance (OR 2.42, 95% CI 0.99 to 5.89).
Homozygotes for the rare allele of SNP2 (OR 2.33, 95% CI 1.13 to 4.81) and the 2-SNP haplotype (OR 2.58, 95% CI 1.26 to 5.28) showed significant associations with statin intolerance.

Structured PICO

Is genetic variation in the COQ2 gene associated with statin intolerance?

Population

291 subjects, comprising 133 who developed myopathy on statin monotherapy and 158 matched controls who tolerated statins without incident or complaint.

Intervention

Genetic variation in the COQ2 gene (SNP1, SNP2, and a 2-SNP haplotype)

Comparator

Matched controls who tolerated statins without incident or complaint (common alleles)

Outcome

Statin intolerance (myopathy)safety

Genetic variation in the COQ2 gene is associated with an increased risk of statin intolerance, suggesting a potential role for the CoQ10 pathway in statin-related muscle symptoms.

Cite This Study

Oh et al. (2007) studied this question.

synapsesocial.com/papers/6a700c185d37378ac1dd199d https://doi.org/10.1186/1476-511x-6-7

Topics

Statin therapy

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Genetic determinants of statin intolerance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Genetic determinants of statin intolerance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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