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May 1, 2003Diabetes CareOpen Access

Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes

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Why the study?

Is urinary 8-OHdG associated with macrovascular and microvascular complications in patients with type 2 diabetes?

Population

96 patients with type 2 diabetes, including a subset of 32 patients from the Kumamoto Study

Comparison

Evaluation of urinary 8-hydroxydeoxyguanosine… vs Conventional insulin injection therapy

Design

Cross-sectional

Authors

TNTakeshi NishikawaTSTakayuki SasaharaSKShinsuke Kiritoshi

Discussion

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Overview

May serve as macrovascular biomarker in type 2 diabetes; leaves open whether intensive insulin mitigates oxidative damage.

Structured PICO

Is urinary 8-OHdG associated with macrovascular and microvascular complications in patients with type 2 diabetes?

P
Population
96 patients with type 2 diabetes, including a subset of 32 patients from the Kumamoto Study
I
Intervention
Evaluation of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels; multiple insulin injection therapy (for the Kumamoto Study subset)
C
Comparator
Conventional insulin injection therapy (for the Kumamoto Study subset)
O
Outcome
Association of urinary 8-OHdG with common carotid intima-media thickness (IMT), coronary heart disease (CHD) risk score, severity of diabetic retinopathy, and urinary albumin excretionsurrogate

Urinary 8-OHdG is a useful biomarker associated with both microvascular and macrovascular complications in patients with type 2 diabetes, and its levels can be reduced by intensive insulin therapy.

Cite This Study

Nishikawa et al. (2003) studied this question.

synapsesocial.com/papers/6a700cf76c240de38cdba91fhttps://doi.org/10.2337/diacare.26.5.1507
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Atherosclerosis Is Retarded by Improved Long-Term Blood Glucose Control in Patients With IDDM1996 · 125 citations
  2. 2Prevalence of Carotid Atherosclerosis in Diabetic Patients Ultrasound high-resolution B-mode imaging on carotid arteries1992 · 281 citations
  3. 3Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index1992 · 645 citations
  4. 4Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8‐hydroxy‐2′‐deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment1997 · 265 citations