Why the study?
Perirenal adipose tissue contains a mixture of brown and white adipocytes, but the origin and plasticity of this cellular heterogeneity remain unknown.
Identifies a unique subpopulation of cold-recruitable adipocytes in mouse perirenal adipose tissue that arises from brown-to-white conversion.
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Adipocyte conversion in mouse PRAT demonstrates depot-specific plasticity; leaves open relevance to human cardiovascular risk.
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of Ucp1 - / Cidea + adipocytes that arises from brown-to-white conversion during postnatal life in the peri-ureter region of mouse PRAT. Cold exposure restores Ucp1 expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.
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Zhang et al. (2023) studied this question.
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