Key result
Beige adipocytes from obese individuals exhibit ~9-fold lower UCP-1 protein induction versus lean controls.
Why the study?
Does the capacity of human subcutaneous white adipose tissue precursor cells to differentiate into beige/brite adipocytes differ between lean and obese individuals?
Does the capacity of human subcutaneous white adipose tissue precursor cells to differentiate into beige/brite adipocytes differ between lean and obese individuals?
Effect estimate: ~9-fold lower
Absolute Event Rate: 6.5% vs 57%
p-value: p=<0.05
Human subcutaneous white adipose tissue cells can differentiate into beige/brite adipocytes, but this thermogenic capacity is significantly reduced in cells derived from obese individuals.
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Reduced browning capacity in obesity may limit therapeutic targeting of beige adipocytes; leaves open in vivo relevance and reversibility.
Carey et al. (2014) studied Obesity (n=17). Obesity vs. Lean individuals was evaluated on Fold-change in UCP-1 protein content post-differentiation (~9-fold lower, p=<0.05). In vitro differentiated beige/brite adipocytes derived from subcutaneous white adipose tissue of obese individuals exhibited a ~9-fold lower induction of UCP-1 protein compared to those from lean individuals.
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