Key result
Brown-like and UCP1-positive adipocytes were detected in 10.3% of lean children and one overweight infant within subcutaneous, perirenal, and visceral depots, but were absent in obese children and adults.
Population
131 children and adolescents (aged 0 to 18 years) and 23 adults
Design
Cross-sectional
Authors
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Brown-like adipocytes linked to leanness in children but absent in obesity; extends distribution data yet leaves causal role open.
Cross-Sectional (n=154)
Absolute Event Rate: 10.3% vs 0%
Brown-like adipocytes persist beyond infancy in subcutaneous and visceral depots of non-obese children, but are absent in obese children and adults.
Rockstroh et al. (2015) conducted a cross-sectional in Healthy (undergoing elective surgery) (n=154). Adipose tissue depots vs. Unilocular white adipose tissue was evaluated on Presence of brown-like and UCP1 positive adipocytes. Brown-like and UCP1-positive adipocytes were detected in 10.3% of lean children and one overweight infant within subcutaneous, perirenal, and visceral depots, but were absent in obese children and adults.
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