The Chemokine Decoy Receptor D6 Prevents Excessive Inflammation and Adverse Ventricular Remodeling After Myocardial Infarction
Population
Murine model of myocardial infarction and human infarcted myocardium samples
Comparison
D6 deficiency and bone marrow chimera experiments vs Wild-type mice (implied)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Supports D6 as protective against post-MI rupture and remodeling in mice; leaves open clinical translation in humans.
Structured PICO
P
Population
Murine model of myocardial infarction and human infarcted myocardium samples
I
Intervention
D6 deficiency (D6-/- mice) and bone marrow chimera experiments
C
Comparator
Wild-type mice (implied)
O
Outcome
Inflammation (chemokine levels, leukocyte infiltration), cardiac rupture, and adverse ventricular remodeling (left ventricle dilation and reduced ejection fraction)surrogate
The chemokine decoy receptor D6 limits pathogenic inflammation and prevents adverse cardiac remodeling and rupture after myocardial infarction.
Cite This Study
Cochain et al. (2012) studied this question.