Gastro-duodenal risks during therapy with new oral anticoagulants and possibility of minimizing them

Relevance . One of the main causes of death and disability in the world is thrombotic diseases, the effective means of prevention of which is the use of anticoagulants. However, their purpose is associated with a certain risk, including the development of gastrointestinal bleeding, which can be fatal. The search for ways to minimize the risks of gastrointestinal bleeding in patients taking new oral anticoagulants is an urgent task of clinical medicine. Aim . Analyze literature data to systematize data on risk factors, treatment options and prevention of gastrointestinal bleeding with the use of new oral anticoagulants in patients treated for pulmonary embolism. Materials and methods . A literature review of the data of domestic and foreign authors on the problem of pathogenesis, clinical manifestations, diagnosis, treatment and prevention of damage to the gastrointestinal tract during treatment of pulmonary embolism was conducted. Results . An attempt was made to systematize the literature data on risk factors, prevention and treatment of gastrointestinal bleeding, taking into account the individual characteristics of the patient, based on evidence. The description of their own clinical observation is provided. Conclusions . When prescribing therapy with new oral anticoagulants, it is necessary to consider benefits and risks, take into account the risk factors for gastrointestinal bleeding, keeping in mind the individual characteristics of the patient and work on their prevention.