In vitro efficacy of cinnamon derived copper nanoconjugates against drug-resistant and sensitive strains of Mycobacterium tuberculosis

Background: Tuberculosis is a chronic infectious disease that is caused by Mycobacterium tuberculosis. In the treatment forefront there are drugs like rifampicin, pyrazinamide, isoniazid that are used. However, long-term use of these medications causes multidrug-resistant bacteria and drug-induced liver damage. In the present study, the effect of the test drug (nano-conjugate) synthesized from Cinnamon was tested for its anti-tuberculosis activity by broth microdilution method. In addition, its efficacy was further tested against multi drug resistant and sensitive strains of tuberculosis. Results: The initial Minimum Inhibitory Concentration of the nanoconjugate was found to be 250 μg/ml against the M. tuberculosis strain H37Rv. Furthermore, it was effective against the sensitive and resistant strains of tuberculosis with a MIC of 250 and 500 μg/ml respectively. Conclusion: The current investigation found a prospective anti-tuberculosis drug candidate which could aid in the rational creation of more potent medications against tuberculosis.