Why the study?
It was unclear whether coagulation or fibrinolysis markers better reflect malignancy and predict recurrence, metastasis, and prognosis in patients with soft tissue sarcomas.
Do plasma markers of coagulation and fibrinolysis predict recurrence, metastasis, and prognosis in patients with soft tissue sarcoma?
Population
64 patients with primary STSs
Comparison
Low vs high levels of plasma TAT, SF, PIC, and DD
Design
Cohort study
Follow-up
5 years
Authors
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Coagulation/fibrinolysis markers may reflect STS tumor microenvironment; leaves open prognostic or therapeutic utility pending validation.
Do plasma markers of coagulation and fibrinolysis predict recurrence, metastasis, and prognosis in patients with soft tissue sarcoma?
Fibrinolysis markers, particularly PIC, are predictive of metastasis and poor prognosis in patients with soft tissue sarcoma.
Asanuma et al. (2022) studied this question.
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