Population
154 mice, including LPL+/- and +/+ in the C57BL/6J background, and LPL+/-LDLR-/- and LPL+/+LDLR-/- in the…
Comparison
Heterozygous lipoprotein lipase deficiency… vs Wild-type LPL combined with the same atherogenic…
Design
Preclinical
Follow-up
3 to 8 months
Authors
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No atherosclerosis increase despite LPL-related dyslipidemia in mice; leaves open potential vascular wall protection for human study.
Heterozygous LPL deficiency exacerbates dyslipidemia but does not increase atherosclerosis in mice, suggesting a potential protective effect of reduced LPL in the vascular wall against the retention of atherogenic lipoproteins.
Semenkovich et al. (1998) studied this question.
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