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Some optically active cyclopropanes were synthesized by using 2-hydroxypinan-3-one as a chiral auxiliary to form a chiral ketimine and followed by Pd(0) catalyzed tandem alkylation and SN, cyclisation of 1,4-dichlorobut-2-ene with chiral ketimines. The yields were about 70% and the diastereoselectivities of reaction were 100%.
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Su et al. (1998) studied this question.
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